IL-1 INHIBITION IN SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

IL-1 inhibition in systemic juvenile idiopathic arthritis

Systemic juvenile idiopathic arthritis (sJIA) is the form of childhood arthritis whose treatment is most challenging.The demonstration of the prominent involvement of interleukin (IL)-1 in disease pathogenesis has provided the rationale for the treatment with biologic medications that antagonize this cytokine.The three IL-1 blockers that have been

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Temporal Stability of Grazed Grassland Ecosystems Alters Response to Climate Variability, While Resistance Stability Remains Unchanged

Environmental change is a crucial driver shaping grassland biodiversity and stability.Both environmental change and stability contain multiple dimensions.Nonetheless, few studies examined multiple dimensions of stability in response to environmental change, especially under the combined effects of climatic variability and grazing intensity.Here, we

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